The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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Preliminary safety, pharmacokinetics, and clinical activity of RG6344 in patients with BRAF V600E-mutant metastatic colorectal cancer (mCRC).
 
Elisa Fontana
Employment - HCA/Sarah Cannon
Leadership - European Organisation for Research and Treatment of Cancer (EORTC)
Consulting or Advisory Role - Astellas Pharma; Bicycle Therapeutics; BMS; Erasca, Inc; Pfizer
Research Funding - Acerta Pharma (Inst); ADC Therapeutics (Inst); Amgen (Inst); Arcus Biosciences (Inst); Artios (Inst); Astellas Pharma (Inst); AstraZeneca (Inst); Basilea (Inst); Bayer (Inst); BeiGene (Inst); Bicycle Therapeutics (Inst); BioNTech SE (Inst); Blueprint Medicines (Inst); Boehringer Ingelheim (Inst); Calithera Biosciences (Inst); Carrick Therapeutics (Inst); CASI Pharmaceuticals (Inst); Clovis Oncology (Inst); Crescendo Biologics (Inst); CytomX Therapeutics (Inst); Daiichi Sankyo (Inst); Deciphera (Inst); Ellipses Pharma (Inst); Erasca, Inc (Inst); Exelixis (Inst); Fore Biotherapeutics (Inst); G1 Therapeutics (Inst); Genentech (Inst); Gilead Sciences (Inst); GlaxoSmithKline (Inst); H3 Biomedicine (Inst); HUTCHMED (Inst); Ignyta/Genentech/Roche (Inst); Immunocore (Inst); Immunomedics (Inst); Incyte (Inst); Instil Bio (Inst); Iovance Biotherapeutics (Inst); Janssen (Inst); Jiangsu Hengrui Medicine (Inst); Kronos Bio (Inst); Lilly (Inst); Lupin Pharmaceuticals (Inst); Macrogenics (Inst); Menarini (Inst); Merck KGaA (Inst); Mereo Biopharma (Inst); Merus (Inst); Millenium Pharamceuticals (Inst); Nerviano Medical Sciences (Inst); Nurix (Inst); Oxford VacMedix (Inst); Pfizer (Inst); Plexxikon (Inst); PMV Pharma (Inst); QED Therapeutics (Inst); Relay Therapeutics (Inst); Repare Therapeutics (Inst); Ribon Therapeutics (Inst); Roche (Inst); Sapience Therapeutics (Inst); Seagen (Inst); SERVIER (Inst); Stemline Therapeutics (Inst); Synthon (Inst); Taiho Pharmaceutical (Inst); Takeda (Inst); Tesaro (Inst); Turning Point Therapeutics (Inst)
Travel, Accommodations, Expenses - Bicycle Therapeutics; Caris Life Sciences; Erasca, Inc; Repare Therapeutics; Sapience Therapeutics; Seagen
 
Maria Vieito Villar
Consulting or Advisory Role - BMS
Speakers' Bureau - Novocure
Research Funding - AstraZeneca (Inst); BeiGene (Inst); Novartis (Inst); Roche; Roche/Genentech (Inst); Taiho Oncology (Inst); Thermo Fisher Scientific (Inst)
Travel, Accommodations, Expenses - Roche
Other Relationship - BMS GmbH & Co. KG (Inst); Debiopharm Group (Inst); HUTCHMED (Inst); Incyte (Inst); Mundipharma (Inst); Novartis (Inst); PharmaMar (Inst); Roche (Inst); SERVIER (Inst); Taiho Oncology (Inst)
 
Eduardo Castanon Alvarez
Honoraria - Bms spain; Gilead Sciences; GlaxoSmithKline; GlaxoSmithKline; MSD Oncology; Pfizer; Pfizer; Roche
Consulting or Advisory Role - BeiGene
Travel, Accommodations, Expenses - AstraZeneca/MedImmune; Bms Spain; MSD; Roche; Roche
 
Ignacio Matos
Consulting or Advisory Role - Daychi; Takeda
Research Funding - Beygene (Inst); Roche (Inst)
Travel, Accommodations, Expenses - Taiho Oncology
 
Oliver Bechter
No Relationships to Disclose
 
Irene Moreno
Consulting or Advisory Role - BOXER CAPITAL LLC; ELLIPSES PHARMA; Guidepoint Global
Speakers' Bureau - Getthi group
Research Funding - DIGICORE (IDEAL4RWE); FUNDACIÓN INTHEOS
 
Catherine Han
Travel, Accommodations, Expenses - MSD
 
Rikke Eefsen
Consulting or Advisory Role - Amgen
Research Funding - Bristol-Myers Squibb/Medarex (Inst)
 
David Pinato
Honoraria - Avammune; Boston Scientific; Bristol-Myers Squibb; Da Volterra; Galapagos NV; Lift Biosciences; Mursla Bio; Parabilis; Roche/Genentech; Starpharma; TERUMO
Consulting or Advisory Role - AstraZeneca; Da Volterra; EISAI; H3 Biomedicine; Ipsen; Mina Therapeutics; Roche
Speakers' Bureau - Bayer; Falk Pharma; Roche; ViiV Healthcare
Research Funding - Bristol-Myers Squibb (Inst); GlaxoSmithKline (Inst); MSD Oncology (Inst)
Travel, Accommodations, Expenses - Bayer; Bristol-Myers Squibb; MSD Oncology
Other Relationship - Wiley
 
Ruth Plummer
Honoraria - AstraZeneca/MedImmune; Bristol-Myers Squibb; MSD Oncology; Novartis Pharmaceuticals UK Ltd.; Sanofi/Aventis
Consulting or Advisory Role - Astex Pharmaceuticals; Bayer; Benevolent AI; Biosceptre; Bristol-Myers Squibb/Medarex; CV6 Therapeutics; Cybrexa Therapeutics; Ellipses Pharma; Genmab; Immunocore; Incyte; Medivir; Nerviano Medical Sciences; Novartis; Novartis; Onxeo; Pierre Fabre; Sanofi/Aventis
Research Funding - AstraZeneca/MedImmune (Inst)
Patents, Royalties, Other Intellectual Property - Named on patent of use of PARP inhibitor rucaparib (Inst)
Travel, Accommodations, Expenses - Bristol-Myers Squibb; MSD Oncology
Other Relationship - Alligator Bioscience; AstraZeneca; GlaxoSmithKline; Sotio
 
Hans Prenen
Honoraria - Amgen; AstraZeneca; Merck
Consulting or Advisory Role - AstraZeneca; Biocartis
 
Gabriel Schnetzler
Employment - Roche
Stock and Other Ownership Interests - Roche
 
Piergiorgio Pettazzoni
Employment - Roche
Stock and Other Ownership Interests - Roche
Research Funding - Roche
 
David Dejardin
Employment - F. Hoffmann LaRoche
Stock and Other Ownership Interests - F. Hoffmann LaRoche
Patents, Royalties, Other Intellectual Property - F. Hoffmann LaRoche
 
Keelara Abiraj
Employment - F. Hoffmann LaRoche
Stock and Other Ownership Interests - F. Hoffmann LaRoche
 
Elisa Cinato
Employment - F. Hoffmann LaRoche
Stock and Other Ownership Interests - F. Hoffmann LaRoche
 
Nick Flinn
Employment - Roche Products Ltd. Welwyn UK
Stock and Other Ownership Interests - Roche
 
Nicole Kratochwil
Employment - F. Hoffmann LaRoche
 
Andreas Roller
Employment - F. Hoffmann LaRoche
Stock and Other Ownership Interests - F. Hoffmann LaRoche
 
Nino Keshelava
Employment - F. Hoffmann LaRoche
Stock and Other Ownership Interests - F. Hoffmann LaRoche; Jazz Pharmaceuticals