The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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Potential impact of non-exonuclease POLE and POLD1 mutations on high and ultrahigh TMB across cancers.
 
Alexander Tsai
No Relationships to Disclose
 
Sachin Kumar Deshmukh
Employment - Caris Life Sciences
 
Sharon Wu
Employment - Caris Life Sciences
Research Funding - Caris Life Sciences
 
Dave Hoon
Consulting or Advisory Role - Guardant Health
 
Wafik El-Deiry
Stock and Other Ownership Interests - Chimerix; Oncoceutics; p53-Therapeutics; SMURF-Therapeutics
Research Funding - Chimerix
Patents, Royalties, Other Intellectual Property - Patent on therapeutic targeting on hypoxia-inducible factors; Patent on TIC10 (ONC201); Patents pending on the use of small molecules to target mutant p53
Other Relationship - Caris Life Sciences
(OPTIONAL) Uncompensated Relationships - Caris Life Sciences
 
Axel Grothey
Honoraria - Cardinal Health; Total Health Conferencing
Consulting or Advisory Role - Amgen (Inst); Bristol-Myers Squibb (Inst); Caris Life Sciences (Inst); Daiichi Sankyo (Inst); Guardant Health (Inst); Lilly (Inst); Natera (Inst); OBI Pharma; Replimune (Inst)
Research Funding - Caris Life Sciences (Inst); Daiichi Sankyo (Inst); Eisai (Inst); Guardant Health (Inst); Lilly (Inst); Natera (Inst); Replimune (Inst)
Travel, Accommodations, Expenses - Cardinal Health; Total Health Conferencing
 
Justin Hwang
Consulting or Advisory Role - Astrin Bio; Tempus
Research Funding - Astrin Biosciences
 
Emmanuel Antonarakis
Consulting or Advisory Role - AADi; AIkido Pharma; Amgen; AstraZeneca; Bayer (Inst); Blue Earth Diagnostics; Corcept Therapeutics; Curium Pharma; Foundation Medicine; Hookipa Pharma; Janssen Biotech; Lilly; Menarini Silicon Biosystems; Merck; Pfizer; Sanofi; Tango Therapeutics; Tempus; Z-Alpha
Research Funding - Astellas Pharma (Inst); Bayer (Inst); Bristol-Myers Squibb (Inst); Macrogenics (Inst); Merck (Inst); Orion Health (Inst)
Patents, Royalties, Other Intellectual Property - Co-inventor of a biomarker technology that has been licensed to Qiagen