The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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Safety, tolerability, and preliminary efficacy results of a phase 1 study of LB2102, a dnTGFßRII armored DLL3-targeted autologous CAR-T cell therapy, in patients with relapsed or refractory small cell lung cancer (SCLC) and large cell neuroendocrine carcinoma (LCNEC).
 
Jacob Sands
Consulting or Advisory Role - Abbvie; Amgen; AstraZeneca; Daiichi Sankyo/UCB Japan; G1 Therapeutics; Gilead Sciences; Jazz Pharmaceuticals; Lilly; Medtronic; Merck; Summit Therapeutics
Research Funding - Harpoon; Novartis (Inst)
Travel, Accommodations, Expenses - AstraZeneca
 
Alberto Chiappori
Stock and Other Ownership Interests - Merck
Consulting or Advisory Role - Ailleron; Amgen; Daiichi Sankyo/Lilly; G1 Therapeutics; Jazz Pharmaceuticals; Merus; Mirati Therapeutics; Sanofi/Regeneron
Speakers' Bureau - Amgen; Blueprint Medicines; Genentech; Takeda
Research Funding - AstraZeneca; Bristol-Myers Squibb; Jazz Pharmaceuticals
Travel, Accommodations, Expenses - Amgen; Takeda
 
Ben Creelan
Consulting or Advisory Role - Achilles Therapeutics plc; AstraZeneca; ER Squibb & Sons, LLC; G1 Therapeutics, Inc; Iovance Biotherapeutics Inc; MJH Healthcare Holdings, LLC; Regeneron
Speakers' Bureau - AstraZeneca; Roche
Research Funding - Cancer Research Institute (Inst); Clinigen Group (Inst); E. R. Squibb & Sons, LLC (Inst); Turnstone Biologics Corp (Inst)
Patents, Royalties, Other Intellectual Property - Patent WO2020263919A1 pending; Patent WO2021163695A2 pending
Travel, Accommodations, Expenses - American Association for Cancer Research; AstraZeneca; ESMO; G1 Therapeutics, Inc; Regeneron; Roche; Society for the Immunotherapy of Cancer
Other Relationship - OmniHealth Media
 
Paul Schwarzenberger
Employment - Legendbiotech
Stock and Other Ownership Interests - Legendbiotech
 
Mythili Koneru
Employment - Legend Biotech
Stock and Other Ownership Interests - Legend Biotech
Travel, Accommodations, Expenses - Legend Biotech
 
Sahista Vahora
Employment - Legend Biotech
Stock and Other Ownership Interests - Abbvie; Bristol-Myers Squibb; Intuitive Surgical; Johnson & Johnson; Legend Biotech; Pfizer; Walgreens
Travel, Accommodations, Expenses - Legend Biotech
 
Christian Davis
Employment - Legend Biotech
Stock and Other Ownership Interests - Glaukos; Legend Biotech
 
Chuan Wang
No Relationships to Disclose
 
Reinhold Munker
Stock and Other Ownership Interests - GE Healthcare; Gilead Sciences
Research Funding - Incyte; Johnson & Johnson; Merck; Novartis; Ono Pharmaceutical
 
Zhonglin Hao
Honoraria - AstraZeneca; BeiGene; Pfizer
Consulting or Advisory Role - Curio Science
Research Funding - Amgen (Inst); Bayer (Inst)
Travel, Accommodations, Expenses - Caris Life Sciences
 
Adam Schoenfeld
Consulting or Advisory Role - Amgen; Bristol-Myers Squibb; Enara Bio; Heat Biologics; Immunocore; Iovance Biotherapeutics; Johnson & Johnson/Janssen; KSQ Therapeutics; Legend Biotech; Lyell Immunopharma; Merck; Oppenheimer; Perceptive Advisors; Prelude Therapeutics; Umoja Biopharma
Research Funding - Achilles Therapeutics; Amgen; Bristol-Myers Squibb; GlaxoSmithKline; Harpoon therapeutics; Instil Bio; Iovance Biotherapeutics; Merck; PACT Pharma
Travel, Accommodations, Expenses - Instil Bio; Iovance Biotherapeutics
Other Relationship - Achilles Therapeutics; Amgen; Bristol-Myers Squibb; GlaxoSmithKline; Harpoon therapeutics; Instil Bio; Iovance Biotherapeutics; Merck; PACT Pharma