The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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A phase I study of AFNT-211, autologous CD4+ and CD8+ T cells engineered to express a high avidity HLA-A*11:01-restricted, KRAS G12V-specific transgenic TCR; CD8a/ß coreceptor; and FAS-41BB switch receptor in patients with advanced or metastatic solid tumors.
 
Soumit Basu
Employment - Affini-T Therapeutics
Stock and Other Ownership Interests - Affini-T Therapeutics
Travel, Accommodations, Expenses - Affini-T Therapeutics
 
Binaish Khan
Employment - Affini-T Therapeutics, Inc
Stock and Other Ownership Interests - Affini-T Therapeutics
Travel, Accommodations, Expenses - Affini-T Therapeutics
 
Francis Payumo
Employment - Affini-T Therapeutics
Stock and Other Ownership Interests - Affini-T Therapeutics
Travel, Accommodations, Expenses - Affini-T Therapeutics
 
Robert Wan
Employment - Affini-T Therapeutics
 
E. Gabriela Chiorean
Consulting or Advisory Role - AADi; Astellas Pharma; BPGbio; Bristol-Myers Squibb/Celgene; IgM Biosciences; Ipsen; Merus; Pfizer; Purple Biotech; Regeneron; Takeda
Research Funding - Affini-T Therapeutics (Inst); BioAtla; Boehringer Ingelheim (Inst); Erasca, Inc (Inst); FibroGen (Inst); Genentech (Inst); Gilead/Forty Seven (Inst); Lonza (Inst); Merck (Inst); Mirati Therapeutics (Inst); Roche (Inst)
Travel, Accommodations, Expenses - Merus
 
Zhubin Gahvari
Honoraria - Curio Science; OncLive/MJH Life Sciences
 
Joel Hecht
Stock and Other Ownership Interests - Actym Therapeutics; Rafael Pharmaceuticals; Trumvira
Consulting or Advisory Role - Agenus; Astellas Pharma; BeiGene; Bristol-Myers Squibb/Medarex; Galvanize Therapeutics; MBQ Pharma; Revolution Medicines; Taiho Pharmaceutical; Xilio Therapeutics
Research Funding - A2 Biotherapeutics (Inst); Affini-T Therapeutics (Inst); Agenus (Inst); Amgen (Inst); Bold Therapeutics (Inst); Camurus (Inst); Cardiff Oncology (Inst); CG Pharmaceuticals (Inst); Crinetics Pharmaceuticals (Inst); Exelixis (Inst); Gilead Sciences (Inst); Gritstone Bio (Inst); Janssen Oncology (Inst); Lyell Immunopharma (Inst); Merck (Inst); Mirati Therapeutics (Inst); Neogene Therapeutics (Inst); NGM Biopharmaceuticals (Inst); Regeneron (Inst); Revolution Medicines (Inst); Seagen (Inst); Tizona Therapeutics, Inc. (Inst); Tizona Therapeutics, Inc. (Inst); Xilio Therapeutics (Inst)
 
Michael Hurwitz
Employment - Arvinas (I); Faeth Therapeutics (I); Gamida Cell (I); Pfizer (I)
Stock and Other Ownership Interests - Arvinas (I)
Consulting or Advisory Role - Affini-T Therapeutics; Bristol-Myers Squibb/Celgene; crispr therapeutics; Exelixis; Janssen; Nektar; pliant; Regeneron; TScan Therapeutics
Research Funding - Achilles Therapeutics; Achilles Therapeutics; Apexigen; Astellas Pharma; AstraZeneca/MedImmune; Bayer; Bristol-Myers Squibb; Corvus Pharmaceuticals; Endocyte; Endocyte; Genentech; Genmab; Innocrin Pharma; Iovance Biotherapeutics; Lilly; Lyell Immunopharma; Lyell Immunopharma; Merck; Nektar; Novartis; Novartis; Pfizer; Progenics; Sanofi/Aventis; Seagen; Synthekine; Torque; Unum Therapeutics; Xilio Therapeutics
 
Rom Leidner
Consulting or Advisory Role - AstraZeneca; Bristol-Myers Squibb/Celgene; CDR-Life; Merck; RAPT Therapeutics; Vir; Vir
Research Funding - Bristol-Myers Squibb (Inst); Incyte (Inst)
Travel, Accommodations, Expenses - Bristol-Myers Squibb/Celgene
Other Relationship - Incyte
 
Heinz-Josef Lenz
Honoraria - Abbvie; Adagene; Bayer; Boehringer Ingelheim; Fulgent Genetics; Janssen Oncology; Jazz Pharmaceuticals; Merck Serono; Merus; Roche
Consulting or Advisory Role - 3T BioSciences; Abbvie; Adagene; Bayer; BMS; Fulgent Genetics; GlaxoSmithKline; Merck Serono; Roche
Travel, Accommodations, Expenses - Bayer; BMS; Merck Serono
 
Meredith Pelster
Honoraria - Castle Biosciences (I)
Consulting or Advisory Role - Arcus Biosciences (Inst); AstraZeneca (Inst); CytomX Therapeutics (Inst); Daiichi Sankyo (Inst); Elevation Oncology (Inst); EMD Serono (Inst); Ipsen (Inst); Jazz Pharmaceuticals (Inst); Pfizer (Inst); Seagen (Inst); Stemline Therapeutics (Inst); Takeda (Inst)
Research Funding - 1200 Pharma (Inst); Abbvie (Inst); Actuate Therapeutics (Inst); Affini-T Therapeutics (Inst); Agenus (Inst); Arcus Biosciences (Inst); Astellas Pharma (Inst); BeiGene (Inst); BioNTech (Inst); Bristol-Myers Squibb (Inst); Codiak Biosciences (Inst); Compass Therapeutics (Inst); CytomX Therapeutics (Inst); CytomX Therapeutics (Inst); Eisai (Inst); Elevation Oncology (Inst); Elicio Therapeutics (Inst); Exelixis (Inst); Fate Therapeutics (Inst); Fog Pharmaceuticals (Inst); Gilead Sciences (Inst); GlaxoSmithKline (Inst); HiberCell (Inst); Immune-Onc Therapeutics (Inst); IMPAC Medical Systems (Inst); Jazz Pharmaceuticals (Inst); Kura Oncology (Inst); Leap Therapeutics (Inst); Neogene (Inst); Novartis (Inst); OncXerna Therapeutics (Inst); Panbela Therapeutics (Inst); Revolution Medicines (Inst); Roche (Inst); Seagen (Inst); SQZ Biotechnology (Inst); Surface Oncology (Inst); Tachyon Therapeutics (Inst); Takeda (Inst); Translational Genomics Research Institute (Inst); TransThera Sciences (Nanjing), Inc. (Inst); ZielBio (Inst)
 
Salman Punekar
Research Funding - A2 Biotherapeutics (Inst); Affini-T Therapeutics (Inst); Amgen (Inst); Astellas Pharma (Inst); Constellation Pharmaceuticals (Inst); NCI (Inst); Neogene Therapeutics (Inst); Prelude Therapeutics (Inst); Revolution Medicines (Inst); Simcere (Inst); Tango Therapeutics (Inst); VITRAC Therapeutics (Inst)
 
Adam Schoenfeld
Consulting or Advisory Role - Amgen; Bristol-Myers Squibb; Enara Bio; Heat Biologics; Immunocore; Iovance Biotherapeutics; Johnson & Johnson/Janssen; KSQ Therapeutics; Legend Biotech; Lyell Immunopharma; Merck; Oppenheimer; Perceptive Advisors; Prelude Therapeutics; Umoja Biopharma
Research Funding - Achilles Therapeutics; Amgen; Bristol-Myers Squibb; GlaxoSmithKline; Harpoon therapeutics; Instil Bio; Iovance Biotherapeutics; Merck; PACT Pharma
Travel, Accommodations, Expenses - Instil Bio; Iovance Biotherapeutics
Other Relationship - Achilles Therapeutics; Amgen; Bristol-Myers Squibb; GlaxoSmithKline; Harpoon therapeutics; Instil Bio; Iovance Biotherapeutics; Merck; PACT Pharma
 
Dan Zhao
Consulting or Advisory Role - Affinit-T; Ipsen
Research Funding - CARsgen Therapeutics (Inst); Mirati Therapeutics (Inst); TriSalus Life Sciences (Inst)
 
Dirk Nagorsen
Employment - Affini-T Therapeutics
Leadership - Affini-T Therapeutics
Stock and Other Ownership Interests - Affini-T Therapeutics; Amgen