The following represents disclosure information provided by authors of this abstract. The program committee has reviewed all presenting author disclosure reports, identified potential conflicts of interest, and implemented strategies to manage those areas of conflict, where appropriate. All relationships are considered compensated. Relationships are self-held unless otherwise noted. I = Immediate Family Member, Inst = My Institution
 
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Safety and efficacy of ZN-A-1041, a highly blood-brain barrier (BBB)–permeable HER2 tyrosine kinase inhibitor (TKI), + trastuzumab deruxtecan (T-DXd) or pertuzumab-trastuzumab (PH) in HER2-positive metastatic breast cancer (HER2+ mBC): Phase Ic expansion results from the ZN-A-1041-101-US trial.
 
Nancy Lin
Stock and Other Ownership Interests - Artera
Consulting or Advisory Role - Artera; AstraZeneca; Daiichi Sankyo; Eisai; Menarini; Olema Pharmaceuticals; Pfizer; Seagen; Shorla Oncology
Research Funding - AstraZeneca (Inst); Genentech (Inst); Merck (Inst); Olema Pharmaceuticals (Inst); Pfizer (Inst); Seagen (Inst); Zion Pharma (Inst)
Patents, Royalties, Other Intellectual Property - Royalties for chapter in Up-to-Date regarding management of breast cancer brain metastases; Royalties, Jones & Bartlett
Travel, Accommodations, Expenses - AstraZeneca; Daiichi Sankyo/Astra Zeneca; Olema Pharmaceuticals
 
Sarah Heeson
Employment - Roche
Stock and Other Ownership Interests - Roche
Other Relationship - Research funding in the form of third-party editing assistance from F. Hoffmann-La Roche Ltd.
 
Mahesh Shivhare
Employment - Roche
Stock and Other Ownership Interests - Roche
Other Relationship - Research funding in the form of third-party editing assistance from F. Hoffmann-La Roche Ltd.
 
Zack Cheng
Employment - Zion Pharma
Other Relationship - Research funding in the form of third-party editing assistance from F. Hoffmann-La Roche Ltd.
 
Ding Zhou
Employment - Zion Pharma
Other Relationship - Research funding in the form of third-party editing assistance from F. Hoffmann-La Roche Ltd.
 
Laura Hiles
Employment - Roche
Stock and Other Ownership Interests - Roche
Other Relationship - Research funding in the form of third-party editing assistance from F. Hoffmann-La Roche Ltd.
 
Rashmi Murthy
Honoraria - AstraZeneca; Genentech; Novartis; Puma Biotechnology; Sanofi; Seagen
Consulting or Advisory Role - AstraZeneca; Boehringer Ingelheim; Genentech/Roche; Johnson & Johnson/Janssen; Novartis; Pfizer; Puma Biotechnology; Sanofi; Seagen
Research Funding - Ambrx (Inst); AstraZeneca (Inst); Daiichi Sankyo (Inst); EMD Serono (Inst); Genentech/Roche (Inst); Pfizer (Inst); Seagen (Inst); Zion Pharma (Inst)
 
Maria Gion
Consulting or Advisory Role - AstraZeneca; Lilly; Pfizer
Speakers' Bureau - AstraZeneca; Gilead Sciences; Novartis; Pfizer
Travel, Accommodations, Expenses - AstraZeneca; Gilead Sciences; Pfizer; Roche
 
Angel Guerrero-Zotano
Consulting or Advisory Role - Exact Sciences; Novartis; Pierre Fabre; Roche
Speakers' Bureau - AstraZeneca; Lilly; Menarini; Novartis
Expert Testimony - AstraZeneca; Lilly; Menarini; Novartis; Pfizer; Pierre Fabre
Travel, Accommodations, Expenses - Gilead Sciences; Menarini; Novartis; Roche
 
Alessandro Viansone
Honoraria - AstraZeneca (Inst); Gilead Sciences (Inst); Lilly (Inst); MSD (Inst); Novartis (Inst); Pfizer (Inst); Roche (Inst); Samsung (Inst); Seagen (Inst)
 
Ciara O'Brien
Employment - Daiichi Sanyo; Lilly; Novartis; Seagen; Stemline Therapeutics
Honoraria - AstraZeneca; Daiichi Sanyo; Lilly; Novartis; Stemline Therapeutics
Consulting or Advisory Role - AstraZeneca; Daiichi Sanyo; Lilly; Novartis; Stemline Therapeutics
Speakers' Bureau - AstraZeneca; daiichi sanyo; Lilly; Stemline Therapeutics
Travel, Accommodations, Expenses - Novartis; Stemline Menarini
 
Weize Huang
Employment - Genentech
Stock and Other Ownership Interests - Roche
Other Relationship - Research funding in the form of third-party editing assistance from F. Hoffmann-La Roche Ltd.
 
Filippo Montemurro
Employment - F. Hoffmann LaRoche
Travel, Accommodations, Expenses - Roche
 
Adam Knott
Employment - Roche
Stock and Other Ownership Interests - Roche
Travel, Accommodations, Expenses - Roche
 
Ethan Zhu
Employment - Zion Pharma
Other Relationship - Research funding in the form of third-party editing assistance from F. Hoffmann-La Roche Ltd.
 
Eleonora Restuccia
Employment - Roche
Stock and Other Ownership Interests - Roche
Other Relationship - Research funding in the form of third-party editing assistance from F. Hoffmann-La Roche Ltd.
 
Carey Anders
Honoraria - AstraZeneca; Athenex; Beigene; Genentech/Roche; Immunomedics; Novartis; Seagen
Consulting or Advisory Role - AstraZeneca; Athenex; Beigene; Eisai; Genentech/Roche; Immunomedics; Roche; Seagen
Research Funding - AstraZeneca (Inst); BeiGene (Inst); Caris Life Sciences (Inst); Caris Life Sciences (Inst); Elucida Oncology (Inst); G1 Therapeutics (Inst); Incyclix Bio (Inst); Lilly (Inst); Novartis Pharmaceuticals UK Ltd. (Inst); Pfizer (Inst); Roche (Inst); Seagen (Inst); Zion Pharma (Inst)
Patents, Royalties, Other Intellectual Property - Jones and Bartlett; Up to Date.com
Travel, Accommodations, Expenses - Eisai