A five-arm, open-label, phase I/lb study to assess safety and tolerability of the oral MEK1/MEK2 inhibitor trametinib (GSK1120212) in combination with chemotherapy or erlotinib in patients with advanced solid tumors.
Carlos Becerra
Honoraria - Lilly
Research Funding - Lilly
Jeffrey R. Infante
No relevant relationships to disclose
Lawrence E. Garbo
No relevant relationships to disclose
Michael S. Gordon
Consultant or Advisory Role - GlaxoSmithKline (U)
Honoraria - GlaxoSmithKline
Research Funding - GlaxoSmithKline
David A. Smith
No relevant relationships to disclose
Fadi S. Braiteh
Consultant or Advisory Role - Amgen; Caris MPI; Celgene; Eisai; Genomic Health; Millennium; Myriad Genetics; Novartis; Pfizer; Spectrum Pharmaceuticals
Research Funding - Genentech; GlaxoSmithKline; Lilly; Merrimack; Mersana; Millennium; Novartis; Pfizer
David R. Gandara
Consultant or Advisory Role - Amgen; AstraZeneca; Bioarray Therapeutics ; Biodesix; Boehringer Ingelheim; Bristol-Myers Squibb; Genentech; ImClone Systems; Merck; Novartis; Response Genetics; Sanofi
Research Funding - Bristol-Myers Squibb; Genentech; ImClone Systems; Lilly; Merck; Novartis
Robert M. Jotte
No relevant relationships to disclose
Karen L. Reckamp
Consultant or Advisory Role - Amgen; Genentech; Tragara Pharmaceuticals
Honoraria - Genentech; Lilly
Research Funding - Agennix; Amgen; Astellas Pharma; GlaxoSmithKline; Pfizer
Filip Janku
No relevant relationships to disclose
Howard A. Burris
No relevant relationships to disclose
Kevin M. Bellew
Employment or Leadership Position - GlaxoSmithKline
Stock Ownership - GlaxoSmithKline
Research Funding - GlaxoSmithKline
Olivia S. Gardner
Employment or Leadership Position - GlaxoSmithKline
Stock Ownership - GlaxoSmithKline
Li Liu
Employment or Leadership Position - GlaxoSmithKline
Stock Ownership - GlaxoSmithKline
Donna S Cox
Employment or Leadership Position - GlaxoSmithKline
Stock Ownership - GlaxoSmithKline
Vijay Gopal Reddy Peddareddigari
Employment or Leadership Position - GlaxoSmithKline
Stock Ownership - GlaxoSmithKline
George R. Blumenschein
Research Funding - GlaxoSmithKline